Folder Guard by WinAbility Software Corporation is a piece of software that can help you protect your privacy by locking your folders and preventing unwanted access. Even if there is no version of Folder Guard for Mac available for download, there are other applications you can use to lock your directories. Here is a list of alternatives to Folder Guard for Mac.
Feel free to add any alternative to Folder Guard for Mac that you know of.
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Folder Guard is a good file manager!