Whats Up by SoftSpot Software is a scrabble game where you have to form words based on the given letters. Even through there is no version of Whats Up for Mac on the developer's website, you can find other similar games that offer the same main functionality. Here is a list with some alternatives to Whats Up for Mac.
Feel free to add any alternative to Whats Up for Mac that you know of.
Suggest Alternatives
I love the word games. I recommend Letter Quest: Remastered. Unusual story + spell cheking. Amazing!